Analog Devices Inc. AD8421BRMZ
- Part No.:
- AD8421BRMZ
- Manufacturer:
- Analog Devices Inc.
- Category:
- Instrumentation, Op Amps, Buffer Amps
- Package:
- 8-TSSOP, 8-MSOP (0.118", 3.00mm Width)
- Datasheet:
-
AD8421BRMZ.pdf
- Description:
- IC INST AMP 1 CIRCUIT 8MSOP
- Quantity:
- Payment:

- Shipping:

Inventory:1,408
Please send an inquiry. Send us your inquiry, and we will respond immediately.
Product details
Overview
AD8421BRMZ from Analog Devices is a low-power, ultralow-noise instrumentation amplifier with 3.2 nV/√Hz input voltage noise, 2.3 mA supply current, and 10 MHz bandwidth at G = 1. It serves as a precision front-end signal conditioner for high-impedance sensors in medical instrumentation and vibration analysis systems.
For engineers reviewing the AD8421BRMZ datasheet, AD8421BRMZ pinout, AD8421BRMZ application, or AD8421BRMZ equivalent, key selection criteria include input bias current (≤0.5 nA), CMRR (≥94 dB at DC, ≥80 dB at 20 kHz), gain flexibility (1–10,000 via single resistor), and robust ±40 V input overvoltage protection relative to supplies.
Technical Context
The AD8421BRMZ uses a current-feedback architecture that maintains 2 MHz bandwidth and 0.8 µs settling time to 0.001% at G = 100, enabling high-channel-count multiplexed data acquisition. Its input stage features 30 GΩ||3 pF impedance and patented protection allowing ±40 V input voltage beyond supply rails without damage.
Gain is set by a single external resistor across RG pins (G = 1 + 9.9 kΩ/RG); the REF pin supports precise output offset adjustment. Input common-mode range extends to −VS + 2.3 V and +VS − 1.8 V at 25°C, supporting wide-supply operation from ±2.5 V to ±18 V (or 5 V–36 V single supply).
Key Specifications
| Parameter | Value and Actual Design Meaning |
|---|---|
| Input Voltage Noise | 3.2 nV/√Hz at 1 kHz - enables resolution of microvolt-level sensor signals without amplifying thermal noise. |
| Supply Current | 2.3 mA max - supports battery-powered portable instrumentation with minimal power budget impact. |
| CMRR (DC, G=1) | 94 dB min - rejects >99.998% of 60 Hz line interference in ECG or strain gauge measurements. |
| Bandwidth (G=1) | 10 MHz - preserves fast transients in vibration analysis up to ~1.6 MHz (−3 dB point). |
| Slew Rate | 35 V/µs - handles 10 V step inputs in ≤0.6 µs to 0.001%, critical for multiplexed ADC driver timing. |
| Input Bias Current | 0.5 nA max - minimizes voltage error across high-Z sources like piezoelectric sensors or pH electrodes. |
| Gain Range | 1 to 10,000 - accommodates full-scale inputs from µV (thermocouples) to volts (LVDTs) using one resistor value. |
Pinout & Package
AD8421BRMZ is housed in an 8-lead MSOP package (3 mm × 3 mm, 0.65 mm pitch) with exposed pad thermally connected to −VS or left floating per layout guidelines.
| Pin/Terminal | Circuit Role | Design Meaning |
|---|---|---|
| 1 (−IN) | Negative differential input | High-impedance node accepting low-level sensor return; protected to −VS + 40 V. |
| 2, 3 (RG) | Gain-setting terminals | Resistor connection points defining gain as G = 1 + 9.9 kΩ/RG; no internal biasing required. |
| 4 (+IN) | Positive differential input | High-impedance node accepting low-level sensor signal; protected to +VS − 40 V. |
| 5 (−VS) | Negative supply rail | Power reference for internal circuitry and exposed thermal pad connection point. |
| 6 (REF) | Output reference level | Low-impedance input for adding precise DC offset (e.g., aligning output to ADC mid-scale). |
| 7 (VOUT) | Differential output | Single-ended output capable of driving 2 kΩ loads with rail-to-rail swing within 1.6 V of supplies. |
| 8 (+VS) | Positive supply rail | Power reference for internal circuitry; supports dual ±2.5 V to ±18 V or single 5 V–36 V operation. |
Key Features
| Feature | Design Value |
|---|---|
| Ultralow input voltage noise | 3.2 nV/√Hz at 1 kHz - preserves SNR when amplifying sub-millivolt biopotentials or MEMS sensor outputs. |
| Input overvoltage protection | ±40 V beyond supplies - eliminates need for external clamping diodes in industrial field I/O modules. |
| Current-feedback architecture | Maintains 2 MHz bandwidth at G = 100 - enables high-gain, high-speed signal conditioning without stability compromises. |
| Single-resistor gain programming | G = 1 + 9.9 kΩ/RG - simplifies BOM management and calibration across gain variants in production test fixtures. |
| Wide supply range | ±2.5 V to ±18 V dual / 5 V–36 V single - supports integration into legacy 5 V systems and high-voltage industrial PLC analog inputs. |
Applications
| Medical Instrumentation | Precision Data Acquisition |
|---|---|
Use Scenario: Amplifying low-amplitude ECG or EEG signals from dry electrodes with high source impedance (>1 MΩ). IC Role / Device Role / Timing Role: Front-end instrumentation amplifier providing initial gain and common-mode rejection before ADC sampling. Use Value: 3.2 nV/√Hz noise floor and 0.5 nA input bias current prevent degradation of microvolt-level neural signals during amplification. | Use Scenario: Conditioning outputs from strain gauges and load cells in automated test equipment with 16-bit ADCs. IC Role / Device Role / Timing Role: Precision gain stage driving multiplexed SAR ADC inputs with <0.8 µs settling to 0.001% at G = 100. Use Value: 94 dB DC CMRR suppresses bridge excitation feedthrough; 2.3 mA quiescent current enables dense channel packing. |
| Vibration Analysis | ADC Driver |
Use Scenario: Signal conditioning for piezoelectric accelerometers in predictive maintenance systems monitoring rotating machinery. IC Role / Device Role / Timing Role: High-bandwidth (10 MHz at G = 1) amplifier preserving transient response of shock events up to 1.6 MHz. Use Value: 35 V/µs slew rate ensures faithful reproduction of high-frequency mechanical resonance peaks without slew-induced distortion. | Use Scenario: Driving the input of AD7685 16-bit SAR ADC in a compact data logger with ±12 V supplies. IC Role / Device Role / Timing Role: Output buffer and level shifter, referenced to ADR435 2.5 V reference via REF pin. Use Value: Output swing to within 1.6 V of rails allows full utilization of ADC's 0–2.5 V input range while maintaining 0.001% settling. |
Equivalent & Alternatives
The following parts are listed as comparable options for similar instrumentation amplifier applications.
| Alternative Part | Technical Difference | Application Difference | Selection Advice |
|---|---|---|---|
| AD8420ARMZ | Higher input bias current (2 nA max), lower CMRR (86 dB min at DC), same 3.2 nV/√Hz noise. | Better suited for cost-sensitive industrial sensors where ultra-low bias current is not required. | Select AD8420ARMZ when budget constraints outweigh need for sub-1 nA bias current in non-medical applications. |
| INA128UA | Higher noise (7 nV/√Hz), higher supply current (700 µA typ), lower bandwidth (1.3 MHz at G = 100). | Optimized for low-power portable devices with moderate performance requirements and simpler PCB layout. | Choose INA128UA only if system-level power budget permits higher quiescent current and noise tolerance exceeds 5 nV/√Hz. |
Compared with AD8420ARMZ and INA128UA, AD8421BRMZ delivers superior noise-performance trade-off (3.2 nV/√Hz at 2.3 mA), wider bandwidth at high gain, and stronger input protection-making it optimal for demanding medical and precision test equipment where signal integrity is non-negotiable.
Availability
AD8421BRMZ is available at Aetrix Electronics and suitable for medical instrumentation, precision data acquisition, and vibration analysis requiring stable component supply across extended temperature ranges (−40°C to +85°C).
Supply support for AD8421BRMZ includes scheduled delivery planning, volume procurement assistance, BOM continuity management, traceable sourcing, and lifecycle availability coordination for OEM customers, industrial embedded developers, connected-device designers, and electronics production programs.
Manufacturer
Analog Devices is a global leader in high-performance analog, mixed-signal, and digital signal processing semiconductors, headquartered in Norwood, MA.
The AD8421 product line targets precision signal conditioning in noise-sensitive measurement systems, emphasizing ultralow noise, low power, and robust input protection for medical, industrial, and test equipment applications.
FAQ
What is the maximum gain achievable with AD8421BRMZ?
The AD8421BRMZ supports a gain range of 1 to 10,000, set by a single external resistor across its RG pins using the formula G = 1 + 9.9 kΩ/RG. At G = 10,000, the required RG is 0.99 Ω, and performance specifications such as bandwidth (0.2 MHz) and settling time (6 µs to 0.001%) are guaranteed per the datasheet. The AD8421BRMZ maintains specified accuracy across this full range when using precision resistors with appropriate tolerance and TCR.
Does AD8421BRMZ require external components for basic operation?
Yes, AD8421BRMZ requires at minimum one external resistor across its RG pins to set gain, and decoupling capacitors (typically 0.1 µF ceramic + 10 µF tantalum per supply rail) for stable operation. The REF pin may be tied to ground or a reference voltage depending on output level-shifting needs. No external compensation or feedback networks are needed-the AD8421BRMZ is fully internally compensated and operates unconditionally stable across its entire gain range.
What is the operating temperature range for AD8421BRMZ?
The AD8421BRMZ is specified for full performance from −40°C to +85°C and operates reliably from −40°C to +125°C. This extended operational range is validated across all grades (AR, BR, ARM, BRM, ACP) and supports deployment in industrial control cabinets and automotive under-hood environments where ambient temperatures exceed standard commercial limits. Thermal resistance (θJA) for the MSOP package is 138.6°C/W, requiring modest PCB copper area for thermal management.
Can AD8421BRMZ be used with single-supply operation?
Yes, AD8421BRMZ supports single-supply operation from 5 V to 36 V. When operated from a single 5 V rail, the input common-mode range is −0.2 V to +3.2 V and output swing reaches within 1.6 V of each rail (i.e., ~0.8 V to ~4.2 V with RL = 2 kΩ). For optimal dynamic range, the REF pin should be biased to mid-supply (e.g., 2.5 V) to center the output. The AD8421BRMZ's rail-swing capability and input protection make it suitable for single-supply portable instrumentation without level-shifting circuitry.
How does the input overvoltage protection work on AD8421BRMZ?
The AD8421BRMZ incorporates proprietary input protection that allows voltages up to ±40 V beyond either supply rail (e.g., −VS + 40 V on −IN, +VS − 40 V on +IN) without damage or latch-up. This is achieved through integrated protection structures that clamp excess voltage while maintaining ultralow input bias current (<0.5 nA) and noise performance. Unlike discrete diode clamps, this on-chip protection does not degrade CMRR or introduce leakage paths-enabling direct connection to industrial field sensors without external protection components.
AD8421BRMZ Specifications
- Product attributes
- Attribute value
- Manufacturer:
- Analog Devices Inc.
- Series:
- -
- Package/Case:
- 8-TSSOP, 8-MSOP (0.118", 3.00mm Width)
- Packaging:
- Tube
- Product Status:
- Active
- Amplifier Type:
- Instrumentation
- Number of Circuits:
- 1
- Output Type:
- -
- Slew Rate:
- 35V/µs
- Gain Bandwidth Product:
- -
- -3db Bandwidth:
- 10 MHz
- Current - Input Bias:
- 100 pA
- Voltage - Input Offset:
- 25 µV
- Current - Supply:
- 2mA
- Current - Output / Channel:
- 65 mA
- Voltage - Supply Span (Min):
- 5 V
- Voltage - Supply Span (Max):
- 36 V
- Operating Temperature:
- -40°C ~ 85°C
- Grade:
- -
- Qualification:
- -
- Mounting Type:
- Surface Mount
- Supplier Device Package:
- 8-MSOP
AD8421BRMZ FAQ
1.How can I place an order for AD8421BRMZ through Aetrix?
Please submit a Request for Quotation (RFQ) for AD8421BRMZ on Aetrix. Our sales agent will provide a competitive quotation and guide you through the order confirmation once you accept the terms.
2.Are the price and stock information for AD8421BRMZ reliable?
The price and inventory of AD8421BRMZ are updated periodically and may fluctuate due to market conditions. Stock and pricing data are typically refreshed every 24 hours. Quotation validity for AD8421BRMZ is usually 5 days.
3.What payment methods are accepted for AD8421BRMZ?
We accept Wire Transfer, PayPal, Credit Card, Western Union, MoneyGram, and Escrow for AD8421BRMZ transactions.
Note: Certain payment methods may incur a processing fee.
4.How is shipping managed for AD8421BRMZ?
AD8421BRMZ orders can be shipped via leading logistics carriers, including DHL, UPS, FedEx, TNT, or Registered Mail.
Once your AD8421BRMZ order is processed, you will receive an email with the shipment details and tracking number.
Note: Tracking information may take up to 24 hours to appear. Express delivery typically takes 3–5 business days.
5.How can I obtain technical support or documentation for AD8421BRMZ?
For technical support, including AD8421BRMZ datasheets, pinout diagrams, or application guidance, please contact our engineering support team. They can provide detailed documentation and assistance for your AD8421BRMZ requirements.
6.How does Aetrix verify that AD8421BRMZ is sourced from the original manufacturer or authorized distributors?
All AD8421BRMZ products on Aetrix are procured from qualified distributors and authorized channels. Our dedicated quality assurance team conducts strict verification, including traceability checks and, if necessary, third-party testing. This ensures that AD8421BRMZ meets industry standards.
7.What is the process for return or replacement of AD8421BRMZ?
All AD8421BRMZ units undergo pre-shipment inspection (PSI). If there is an issue with AD8421BRMZ, returns or replacements are accepted under the following conditions:
1.Quantity discrepancies, incorrect items, or visible external defects (such as breakage or corrosion), acknowledged by Aetrix.
2.The issue is reported within 90 days of delivery.
3.The AD8421BRMZ part is unused and in its original packaging.
Return procedure for AD8421BRMZ:
1.Submit a request within 90 days.
2.Obtain a Return Material Authorization (RMA) from Aetrix.
AD8421BRMZ Tags

-
LM358DT
STMicroelectronics

-
LM358DR
Texas Instruments

-
LM2904DR
Texas Instruments

-
LM358ADR
Texas Instruments
-
LM2904DGKR
Texas Instruments
-
LM324DR
Texas Instruments

-
MCP6006T-E/OT
Microchip Technology

-
MCP6006UT-E/OT
Microchip Technology

-
LM324PWR
Texas Instruments

-
LM2902PWR
Texas Instruments
-
LM2902DR
Texas Instruments

-
LM358P
Texas Instruments
Tech Hub
A practical engineering guide to 3.3V and 5V logic compatibility, input thresholds, resistor dividers, translator ICs, MOSFET level shifting, I2C pull-ups, timing limits and power-sequencing risks.
The 74HC595 uses push-pull logic outputs, while the TPIC6B595 uses 50 V open-drain DMOS sinks for higher-power loads. This guide compares timing, current limits, 3.3 V interfacing, load wiring, thermal…
The 74HC595 converts serial data into eight stable parallel outputs. This guide covers pin functions, shift and storage timing, OE and MR behavior, drive-current limits, cascading, voltage compatibilit…
A technical comparison of level-sensitive latches and edge-triggered flip-flops, covering timing windows, setup and hold limits, master–slave operation, time borrowing, race-through, HDL inference and…
A D latch stores one bit while Enable controls when data can pass. This reference covers gate-level operation, truth tables, transparency, setup and hold timing, LE versus OE, common ICs and practical …
An SR latch stores one bit through cross-coupled feedback. This engineering reference covers NOR and NAND implementations, truth tables, forbidden-state recovery, gated operation, switch debouncing, fa…
Latch circuits retain one bit through feedback. This technical reference covers SR and D latches, truth tables, transparency, timing limits, latch-versus-flip-flop behavior, applications and common log…
An engineering guide to LED driver operation, constant-current and constant-voltage outputs, linear and switching topologies, dimming, IC selection, calculations, replacement compatibility, and fault c…
Operational amplifier guide covering op amp basics, feedback, ideal vs real op amps, common configurations, buffer circuits, offset, bias current, gain-bandwidth, slew rate, rail-to-rail limits and sel…
Jumper cables guide covering safe connection order, red and black clamp placement, final ground connection, cable gauge, length, clamp quality, copper vs CCA cables, jump starter comparison and battery…

