Texas Instruments INA321EA/2K5G4
- Part No.:
- INA321EA/2K5G4
- Manufacturer:
- Texas Instruments
- Category:
- Instrumentation, Op Amps, Buffer Amps
- Package:
- 8-TSSOP, 8-MSOP (0.118", 3.00mm Width)
- Datasheet:
-
INA321EA/2K5G4.pdf
- Description:
- IC INST AMP 1 CIRCUIT 8VSSOP
- Quantity:
- Payment:

- Shipping:

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Product details
Overview
INA321EA/2K5G4 from Texas Instruments is a rail-to-rail output, micropower CMOS instrumentation amplifier in MSOP-8 package, configured for fixed 5V/V gain with external resistor programmability (G = 5 + 5·R₂/R₁), ±200 µV offset voltage, 94 dB CMRR at DC, and 500 kHz bandwidth - deployed in ECG front-ends and bridge sensor signal conditioning where low quiescent current (40 µA/channel) and −55°C to +125°C operation are critical.
For engineers reviewing the INA321EA/2K5G4 datasheet, INA321EA/2K5G4 pinout, INA321EA/2K5G4 application, or INA321EA/2K5G4 equivalent, key selection criteria include micropower shutdown (<1 µA), rail-to-rail output swing (V⁺ − 0.02 V), high-precision gain accuracy (±0.02% at G=5), input bias current (10 pA), and compatibility with single-supply (2.7–5.5 V) industrial and medical sensing systems.
Technical Context
The INA321EA/2K5G4 implements a three-op-amp instrumentation architecture with internal gain-setting resistors for nominal G = 5, extended via external R₁/R₂ to 5–1000 V/V. Its CMOS input stage delivers 10¹³ Ω input impedance and 10 pA bias current, enabling direct interfacing with high-impedance sensors like thermistors and RTDs without loading error.
It features a dedicated shutdown pin that reduces quiescent current to <1 µA within nanoseconds while placing the output in high-impedance state - ideal for time-multiplexed sensor arrays. The REF pin defines output zero level and enables offset trimming, but requires low-impedance drive to maintain >90 dB CMRR up to 3 kHz.
Key Specifications
| Parameter | Value and Actual Design Meaning |
|---|---|
| Gain Accuracy | ±0.02% at G = 5 - ensures sub-0.1 mV error in 5 V full-scale bridge outputs at room temperature |
| Input Offset Voltage | ±200 µV max - enables resolution of <10 µV differential signals after gain, critical for ECG baseline stability |
| CMRR | 94 dB at DC, ≥77 dB over −55°C to +125°C - rejects 50/60 Hz line noise in industrial field meters and physiological amplifiers |
| Bandwidth | 500 kHz at G = 5 - supports fast transient capture in A/D converter signal conditioning up to 100 kSPS |
| Quiescent Current | 40 µA per channel - allows battery-powered operation for >1 year on a CR2032 in intermittent-sampling sensor nodes |
| Rail-to-Rail Output | VOUT swings to (V+) − 20 mV - eliminates need for level-shifting when driving 2.5 V reference ADCs from 3.3 V supply |
| Operating Temp | −55°C to +125°C - qualified for under-hood automotive instrumentation and downhole oilfield sensor modules |
Pinout & Package
INA321EA/2K5G4 is packaged in MSOP-8 (DGK) with exposed thermal pad, footprint compatible with industry-standard 3 mm × 3 mm space-constrained PCB layouts.
| Pin/Terminal | Circuit Role | Design Meaning |
|---|---|---|
| 1 (RG) | Gain Resistor Terminal | Connects to external R₂ to set gain per G = 5 + 5·R₂/R₁; open for G = 5, shorted to VOUT for unity-gain buffer mode |
| 2 (VIN−) | Inverting Input | Differential input node; requires matched bias return path (e.g., dual 1 MΩ to REF) to prevent CM saturation |
| 3 (VIN+) | Non-inverting Input | Differential input node; high-impedance (10¹³ Ω) CMOS input accepts microvolt-level bridge outputs directly |
| 4 (V−) | Negative Supply | Ground or negative rail; must be decoupled with 0.1 µF ceramic capacitor placed ≤2 mm from pin |
| 5 (Shutdown) | Enable Control | Pull <0.8 V (at 5 V supply) to enter <1 µA shutdown; rise time <1 µs enables rapid multiplexing between sensor channels |
| 6 (V+) | Positive Supply | 2.7–5.5 V single supply; internal ESD diodes clamp inputs to rails ±0.5 V - external current limiting required beyond that range |
| 7 (VOUT) | Amplified Output | Rail-to-rail output referenced to REF; drives ≥10 kΩ loads directly; buffers needed for <600 Ω or capacitive ADC inputs |
| 8 (REF) | Output Reference | Defines zero-output level; must be driven low-impedance (≤160 Ω) to preserve CMRR; used for offset trimming via external op-amp |
Key Features
| Feature | Design Value |
|---|---|
| Micropower Shutdown | Draws <1 µA during sleep, enabling battery life extension in portable ECG monitors and wireless sensor nodes |
| Laser-Trimmed Gain Accuracy | ±0.02% at G = 5 minimizes calibration overhead in factory-trimmed field utility meters |
| High CMRR Over Frequency | Maintains >75 dB CMRR up to 3 kHz - suppresses harmonics in motor-driven industrial equipment |
| Single-Supply Flexibility | Operates from 2.7 V to 5.5 V with rail-to-rail output - eliminates dual-supply complexity in PCMCIA cards and IoT edge nodes |
| Low Input Bias Current | 10 pA maximum avoids voltage drop across high-Z sources (e.g., pH electrodes, piezoresistive sensors) |
Applications
| Industrial Sensor Amplifiers | Physiological Amplifiers |
|---|---|
Use Scenario: Amplifying mV-level differential output from a 350 Ω strain gauge in a load cell under vibration and temperature cycling. IC Role / Device Role / Timing Role: Precision instrumentation amplifier providing fixed G = 5 gain, rejecting common-mode noise from 4–20 mA loop coupling and 50 Hz mains interference. Use Value: 94 dB CMRR and ±200 µV offset enable <0.1% full-scale error across −40°C to +85°C without recalibration. | Use Scenario: Front-end amplification of 1–2 mV ECG signals from limb electrodes in wearable fitness trackers. IC Role / Device Role / Timing Role: Low-noise, micropower IA with shutdown control for duty-cycled acquisition to extend coin-cell battery life. Use Value: 40 µA quiescent current and <1 µA shutdown allow >12-month operation on CR2032; 10 pA bias prevents electrode polarization drift. |
| A/D Converter Signal Conditioning | Differential Line Receivers with Gain |
Use Scenario: Driving ADS7818 12-bit SAR ADC input with 500 kHz bandwidth requirement in portable data loggers. IC Role / Device Role / Timing Role: Signal conditioner delivering rail-to-rail output swing (V⁺ − 20 mV) into capacitive CDAC input without external buffer. Use Value: 500 kHz bandwidth and 0.4 V/µs slew rate ensure <0.1% settling in <8 µs for 2 V step - matching ADC sampling clock timing budgets. | Use Scenario: Receiving balanced analog signals from 100 Ω twisted-pair lines in building automation controllers. IC Role / Device Role / Timing Role: Differential receiver with programmable gain (G = 5–100) rejecting ground-loop noise and RF ingress. Use Value: 110 dB crosstalk (dual version) and 94 dB CMRR suppress inter-channel interference in multi-zone HVAC monitoring. |
Equivalent & Alternatives
The following parts are listed as comparable options for similar instrumentation amplifier applications.
| Alternative Part | Technical Difference | Application Difference | Selection Advice |
|---|---|---|---|
| INA333AIDGKR | Lower quiescent current (17 µA), lower offset (±25 µV), but narrower temp range (−40°C to +125°C); same MSOP-8 package | Better suited for ultra-low-power wearable biosensors, less suitable for extended-temperature automotive or aerospace use | Select INA333AIDGKR only if operating temperature stays above −40°C and sub-25 µV offset is mandatory |
| AD8221ARMZ | Higher bandwidth (825 kHz), higher PSRR (120 dB), but higher IQ (350 µA) and no shutdown; 8-lead SOIC package | Preferred for high-speed test equipment requiring fast settling, not for battery-powered or space-constrained designs | Choose AD8221ARMZ when bandwidth >800 kHz and power budget >300 µA/channel is acceptable |
Compared with INA333AIDGKR and AD8221ARMZ, the INA321EA/2K5G4 uniquely balances extended temperature operation (−55°C to +125°C), micropower shutdown (<1 µA), and MSOP-8 footprint - making it optimal for ruggedized industrial sensors and automotive body electronics where reliability and board area are constrained.
Availability
INA321EA/2K5G4 is available at Aetrix Electronics and suitable for industrial sensor amplifiers, physiological monitoring systems, A/D converter signal conditioning, and differential line receivers requiring stable component supply across extended temperature ranges and long production lifecycles.
Supply support for INA321EA/2K5G4 includes scheduled delivery planning, volume procurement assistance, BOM continuity management, traceable sourcing, and lifecycle availability coordination for OEM customers, industrial embedded developers, connected-device designers, and electronics production programs.
Manufacturer
Texas Instruments is a global semiconductor leader specializing in analog and embedded processing technologies, with decades of expertise in precision amplifiers and signal chain solutions.
The INA321 family was designed specifically for low-power, high-accuracy instrumentation in harsh environments - targeting bridge-based industrial sensors, medical diagnostics, and field utility metering where micropower, rail-to-rail output, and wide temperature range are non-negotiable.
FAQ
What is the gain configuration of INA321EA/2K5G4 and how is it set?
The INA321EA/2K5G4 is internally configured for G = 5, but supports user-programmable gains from 5 V/V to 1000 V/V using external resistors R₁ and R₂ per the equation G = 5 + 5·(R₂/R₁). Pin 1 (RG) connects to R₂; R₁ bridges RG and REF. No external resistors yield G = 5. This flexibility allows precise gain tailoring without changing the INA321EA/2K5G4 itself.
Does INA321EA/2K5G4 support true rail-to-rail output swing?
Yes, the INA321EA/2K5G4 delivers rail-to-rail output swing - specifically, VOUT reaches within 20 mV of V+ and V− rails when gain ≥10 and load ≥25 kΩ. At G = 5, output swing is limited to (V+) − 50 mV. This behavior is confirmed in Electrical Characteristics tables and Typical Characteristics curves for Output Voltage Swing vs Load Resistance.
What is the purpose of the REF pin on INA321EA/2K5G4 and how should it be driven?
The REF pin on INA321EA/2K5G4 sets the output's zero-reference level and enables offset trimming. It must be driven with low impedance (≤160 Ω) to preserve CMRR; exceeding this resistance degrades CMRR to ≤80 dB. A buffered voltage (e.g., from OPA336) or precision DAC output is recommended. Direct connection to mid-supply via resistive divider is acceptable only if source impedance is minimized.
Can INA321EA/2K5G4 operate from a single 3.3 V supply?
Yes, the INA321EA/2K5G4 is fully specified for single-supply operation from 2.7 V to 5.5 V. At 3.3 V, it maintains 40 µA quiescent current, ±200 µV offset, 94 dB CMRR, and 500 kHz bandwidth. Input common-mode range extends from 0.55 V to 3.8 V (at VS = 5 V) - scaled proportionally at 3.3 V - and REF must remain ≥1.2 V below V+ for proper A2 amplifier operation.
How does the shutdown feature of INA321EA/2K5G4 behave during system sleep cycles?
The shutdown pin on INA321EA/2K5G4 pulls the amplifier into sub-1 µA quiescent state within nanoseconds when driven below 0.8 V (at 5 V supply); recovery to full operation takes <1 µs. During shutdown, the output enters high-impedance state - enabling safe multiplexing of multiple INA321EA/2K5G4 channels onto shared ADC inputs without cross-talk or loading.
INA321EA/2K5G4 Specifications
- Product attributes
- Attribute value
- Manufacturer:
- Texas Instruments
- Series:
- -
- Package/Case:
- 8-TSSOP, 8-MSOP (0.118", 3.00mm Width)
- Packaging:
- Tape & Reel (TR)
- Product Status:
- Discontinued at Digi-Key
- Amplifier Type:
- Instrumentation
- Number of Circuits:
- 1
- Output Type:
- Rail-to-Rail
- Slew Rate:
- 0.4V/µs
- Gain Bandwidth Product:
- -
- -3db Bandwidth:
- 500 kHz
- Current - Input Bias:
- 0.5 pA
- Voltage - Input Offset:
- 200 µV
- Current - Supply:
- 40µA
- Current - Output / Channel:
- 16 mA
- Voltage - Supply Span (Min):
- 2.5 V
- Voltage - Supply Span (Max):
- 5.5 V
- Operating Temperature:
- -55°C ~ 125°C
- Grade:
- -
- Qualification:
- -
- Mounting Type:
- Surface Mount
- Supplier Device Package:
- 8-VSSOP
INA321EA/2K5G4 FAQ
1.How can I place an order for INA321EA/2K5G4 through Aetrix?
Please submit a Request for Quotation (RFQ) for INA321EA/2K5G4 on Aetrix. Our sales agent will provide a competitive quotation and guide you through the order confirmation once you accept the terms.
2.Are the price and stock information for INA321EA/2K5G4 reliable?
The price and inventory of INA321EA/2K5G4 are updated periodically and may fluctuate due to market conditions. Stock and pricing data are typically refreshed every 24 hours. Quotation validity for INA321EA/2K5G4 is usually 5 days.
3.What payment methods are accepted for INA321EA/2K5G4?
We accept Wire Transfer, PayPal, Credit Card, Western Union, MoneyGram, and Escrow for INA321EA/2K5G4 transactions.
Note: Certain payment methods may incur a processing fee.
4.How is shipping managed for INA321EA/2K5G4?
INA321EA/2K5G4 orders can be shipped via leading logistics carriers, including DHL, UPS, FedEx, TNT, or Registered Mail.
Once your INA321EA/2K5G4 order is processed, you will receive an email with the shipment details and tracking number.
Note: Tracking information may take up to 24 hours to appear. Express delivery typically takes 3–5 business days.
5.How can I obtain technical support or documentation for INA321EA/2K5G4?
For technical support, including INA321EA/2K5G4 datasheets, pinout diagrams, or application guidance, please contact our engineering support team. They can provide detailed documentation and assistance for your INA321EA/2K5G4 requirements.
6.How does Aetrix verify that INA321EA/2K5G4 is sourced from the original manufacturer or authorized distributors?
All INA321EA/2K5G4 products on Aetrix are procured from qualified distributors and authorized channels. Our dedicated quality assurance team conducts strict verification, including traceability checks and, if necessary, third-party testing. This ensures that INA321EA/2K5G4 meets industry standards.
7.What is the process for return or replacement of INA321EA/2K5G4?
All INA321EA/2K5G4 units undergo pre-shipment inspection (PSI). If there is an issue with INA321EA/2K5G4, returns or replacements are accepted under the following conditions:
1.Quantity discrepancies, incorrect items, or visible external defects (such as breakage or corrosion), acknowledged by Aetrix.
2.The issue is reported within 90 days of delivery.
3.The INA321EA/2K5G4 part is unused and in its original packaging.
Return procedure for INA321EA/2K5G4:
1.Submit a request within 90 days.
2.Obtain a Return Material Authorization (RMA) from Aetrix.
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