STMicroelectronics STM32L452CCU6
- Part No.:
- STM32L452CCU6
- Manufacturer:
- STMicroelectronics
- Category:
- Microcontrollers
- Package:
- 48-UFQFN Exposed Pad
- Datasheet:
-
STM32L452CCU6.pdf
- Description:
- IC MCU 32BIT 256KB FLSH 48UFQFPN
- Quantity:
- Payment:

- Shipping:

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Product details
Overview
STM32L452CCU6 from STMicroelectronics is an ultra-low-power Arm® Cortex®-M4 32-bit MCU with FPU, operating up to 80 MHz (100 DMIPS), featuring 256 KB Flash, 64 KB SRAM, and integrated analog peripherals including a 12-bit 5 Msps ADC, dual 12-bit DACs, and ultra-low-power comparators. It supports external SMPS for 36 µA/MHz run efficiency and operates across -40 °C to 85 °C in UFBGA64 (5×5) package - deployed in battery-powered medical sensors and portable industrial data loggers.
For engineers reviewing the STM32L452CCU6 datasheet, STM32L452CCU6 pinout, STM32L452CCU6 application, or STM32L452CCU6 equivalent, key selection criteria include verified low-power mode current (22 nA Shutdown, 375 nA Standby+RTC), USB 2.0 full-speed crystal-less operation, SAI audio interface support, and FlexPowerControl architecture enabling BAM and sub-µA wake-up timing.
Technical Context
The STM32L452CCU6 implements an Adaptive Real-time Accelerator (ART Accelerator™) enabling zero-wait-state execution from Flash at 80 MHz, paired with a Memory Protection Unit (MPU) and interconnect matrix for deterministic peripheral arbitration. Its power architecture integrates dual voltage regulators (LDO/SMPS), brown-out reset (BOR), and VBAT domain supporting RTC + 32×32-bit backup registers.
Clock system includes dual PLLs (system/audio), auto-trimmed multispeed oscillator (±0.25%), 4–48 MHz HSE, 32 kHz LSE, and internal 48 MHz clock recovery - enabling precise timing for USB, audio, and ADC sampling without external crystals. Analog subsystem features independent supply domains, hardware oversampling (up to 16-bit), and built-in PGA for sensor signal conditioning.
Key Specifications
| Parameter | Value and Actual Design Meaning |
|---|---|
| Core | Arm Cortex-M4 with FPU, 80 MHz max, 100 DMIPS - enables real-time DSP and control algorithms without external co-processor. |
| Memory | 256 KB Flash (single-bank), 64 KB SRAM (32 KB with parity) - sufficient for secure firmware + OTA update partitioning. |
| Power Efficiency | 36 µA/MHz @ 3.3 V (SMPS mode) - reduces battery drain in always-on edge nodes by >50% vs LDO-only operation. |
| Analog Peripherals | 12-bit 5 Msps ADC (200 µA/Msps), 2×12-bit DACs, 2×ultra-low-power comparators - supports high-fidelity sensor acquisition and analog feedback loops. |
| Low-Power Modes | 22 nA Shutdown (5 wakeup pins), 375 nA Standby+RTC - enables multi-year operation on coin-cell batteries. |
| Communication | USB 2.0 FS crystal-less, SAI, 4×I²C FM+, 3×USART, LPUART, CAN 2.0B - supports mixed-signal connectivity in constrained environments. |
| Package | UFBGA64 (5×5 mm, 0.5 mm pitch) - compact footprint suitable for space-limited wearable and IoT modules. |
Pinout & Package
STM32L452CCU6 is housed in a 64-ball Ultra-Fine Pitch Ball Grid Array (UFBGA64) package with 0.5 mm ball pitch and 5×5 mm body size, optimized for high-density PCB layouts and thermal performance in battery-powered applications.
| Pin/Terminal | Circuit Role | Design Meaning |
|---|---|---|
| VDD, VDDA, VDDIO2 | Power supply inputs | Separate domains for digital core (VDD), analog (VDDA), and I/O (VDDIO2) enable noise isolation and flexible rail sequencing. |
| VSS, VSSA, VSSIO2 | Ground returns | Dedicated analog ground (VSSA) and I/O ground (VSSIO2) minimize coupling between sensitive analog paths and switching I/O. |
| PA0–PA15, PB0–PB15, PC0–PC15, PD0–PD15, PE0–PE15 | General-purpose I/Os | Up to 51 GPIOs (most 5 V-tolerant); support 17 alternate functions per pin including USB, SAI, CAN, and ADC channels. |
| NRST | Active-low reset input | Asynchronous reset with internal pull-up; compatible with external reset supervisors and push-button debouncing circuits. |
| BOOT0 | Boot mode selection | Configures boot source (system memory, embedded Flash, or SRAM) during power-up; requires external pull-down for normal Flash execution. |
| VBAT | Backup power supply | Direct connection to coin cell or supercapacitor powers RTC and 32×32-bit backup registers during main power loss. |
Key Features
| Feature | Design Value |
|---|---|
| FlexPowerControl architecture | Enables 7 low-power modes (Shutdown, Stop 2, Standby+RTC) with validated current specs - critical for energy harvesting and battery longevity. |
| ART Accelerator™ | Zero-wait-state Flash execution at 80 MHz - eliminates CPU stalls during code fetch, improving real-time determinism and reducing average power. |
| Independent analog supply domain | VDDA/VSSA separation allows clean 2.5 V reference buffer output and <200 µA/Msps ADC power - essential for precision sensor front-ends. |
| Crystal-less USB 2.0 FS | Eliminates 12 MHz crystal and associated load capacitors - reduces BOM cost and PCB area while maintaining ±0.25% timing accuracy via CRS. |
| SAI serial audio interface | Supports I²S, PCM, and SPDIF protocols with DMA-driven transfers - enables voice capture/playback in resource-constrained edge devices without external codec. |
Applications
| Wearable Health Monitor | Industrial Wireless Sensor Node |
|---|---|
|
Use Scenario: Continuous ECG/PPG signal acquisition and local feature extraction before BLE transmission. IC Role / Device Role / Timing Role: Main controller executing real-time filtering, ADC oversampling, and low-latency USB/SAI audio streaming. Use Value: 375 nA Standby+RTC extends battery life to >2 years on CR2032; 12-bit ADC + PGA enables clinical-grade analog front-end integration. |
Use Scenario: Multi-sensor (temp/humidity/pressure) node with LoRaWAN backhaul and local data logging. IC Role / Device Role / Timing Role: System-on-chip managing sensor polling, CRC-protected Flash storage, and LPUART wake-up from Stop 2 mode. Use Value: 22 nA Shutdown mode minimizes quiescent drain; quad-SPI interface supports external NOR Flash for firmware resilience. |
| Portable Medical Diagnostic Tool | Smart Home Energy Monitor |
|
Use Scenario: Handheld ultrasound probe with analog beamforming and real-time image processing. IC Role / Device Role / Timing Role: High-performance MCU handling time-critical DMA transfers between ADC, SRAM, and SAI for echo data streaming. Use Value: 80 MHz Cortex-M4+FPU delivers 273.55 CoreMark® score - sufficient for floating-point FFT and envelope detection in firmware. |
Use Scenario: DIN-rail mounted electricity meter with isolated RS-485, tamper detection, and local display. IC Role / Device Role / Timing Role: Primary controller interfacing with shunt-based current sensing, RTC calendar, and CAN bus for grid communication. Use Value: CAN 2.0B interface enables interoperability with legacy SCADA systems; 160°C temp grade supports enclosure mounting near transformers. |
Equivalent & Alternatives
The following parts are listed as comparable options for similar ultra-low-power MCU applications.
| Alternative Part | Technical Difference | Application Difference | Selection Advice |
|---|---|---|---|
| STM32L476RG | 512 KB Flash, 128 KB SRAM, no SAI, higher active current (42 µA/MHz SMPS) | Better suited for GUI-rich HMI applications requiring larger code space but less optimized for audio or strict sub-µA standby. | Select when needing larger memory and Ethernet MAC; avoid if SAI or lowest standby current is mandatory. |
| STM32L552RE | ARM TrustZone®, 256 KB Flash, 128 KB SRAM, 110 nA Shutdown, no USB crystal-less | Designed for secure firmware updates and cryptographic operations; lacks crystal-less USB and has higher shutdown current. | Choose for certified secure boot and PSA Level 1 compliance; not recommended for USB audio or coin-cell lifetime targets. |
Compared with STM32L452CCU6, STM32L476RG offers more memory but sacrifices audio capability and ultra-low-power precision, while STM32L552RE adds security at the cost of USB convenience and standby efficiency - making STM32L452CCU6 optimal for balanced audio-enabled, battery-critical designs.
Availability
STM32L452CCU6 is available at Aetrix Electronics and suitable for wearable health monitors, industrial wireless sensor nodes, portable diagnostic tools, and smart home energy monitors requiring stable component supply and long-term lifecycle assurance.
Supply support for STM32L452CCU6 includes scheduled delivery planning, volume procurement assistance, BOM continuity management, traceable sourcing, and lifecycle availability coordination for OEM customers, industrial embedded developers, connected-device designers, and electronics production programs.
Manufacturer
STMicroelectronics is a global semiconductor leader headquartered in Geneva, designing and manufacturing microcontrollers, power ICs, sensors, and automotive semiconductors with emphasis on energy efficiency and industrial reliability.
The STM32L4 series targets ultra-low-power embedded applications demanding rich analog integration, secure firmware execution, and extended battery life - particularly in medical, metering, and portable industrial equipment.
FAQ
Does STM32L452CCU6 support crystal-less USB operation?
Yes. The device integrates a Clock Recovery System (CRS) that synchronizes the internal 48 MHz RC oscillator to USB SOF packets, enabling full-speed USB 2.0 operation without an external 12 MHz crystal. This is validated per USB-IF specifications and documented in Section 3.33 of DS11912 Rev 7.
What is the maximum allowed VDD voltage and absolute maximum rating for I/O pins?
The absolute maximum VDD rating is 4.0 V, with recommended operating range of 1.71 V to 3.6 V. All I/O pins except BOOT0 and NRST are 5 V-tolerant up to 5.5 V when VDD is ≥ 2.0 V, as specified in Table 20 (Voltage characteristics) and Table 24 (I/O port characteristics) of the datasheet.
How many wakeup sources are available in Stop 2 mode?
Stop 2 mode supports wakeup from 5 dedicated wakeup pins (WKUP1–WKUP5), plus additional sources including LPUART, I²C address match, RTC alarm, and external interrupt lines mapped to EXTI0–EXTI15. Full listing appears in Table 4 of DS11912 Rev 7 under "STM32L452xx modes overview".
Is the 12-bit ADC capable of hardware oversampling to higher resolution?
Yes. The ADC supports configurable hardware oversampling ratios (2× to 256×) with automatic right-shift, achieving effective resolutions up to 16 bits. This is implemented in the ADC's oversampler unit and requires no CPU intervention - confirmed in Section 3.15 and Table 33 of the datasheet.
STM32L452CCU6 Specifications
- Product attributes
- Attribute value
- Manufacturer:
- STMicroelectronics
- Package/Case:
- 48-UFQFN Exposed Pad
- Series:
- STM32L4
- Packaging:
- Tray
- Product Status:
- Active
- Programmable:
- Not Verified
- Core Processor:
- ARM® Cortex®-M4
- Core Size:
- 32-Bit Single-Core
- Speed:
- 80MHz
- Connectivity:
- CANbus, I2C, IrDA, LINbus, QSPI, SAI, SPI, UART/USART, USB
- Peripherals:
- Brown-out Detect/Reset, DMA, PWM, WDT
- Number of I/O:
- 38
- Program Memory Size:
- 256KB (256K x 8)
- Program Memory Type:
- FLASH
- EEPROM Size:
- -
- RAM Size:
- 160K x 8
- Voltage - Supply (Vcc/Vdd):
- 1.71V ~ 3.6V
- Data Converters:
- A/D 10x12b; D/A 1x12b
- Oscillator Type:
- Internal
- Operating Temperature:
- -40°C ~ 85°C (TA)
- Grade:
- -
- Qualification:
- -
- Mounting Type:
- Surface Mount
- Supplier Device Package:
STM32L452CCU6 FAQ
1.How can I place an order for STM32L452CCU6 through Aetrix?
Please submit a Request for Quotation (RFQ) for STM32L452CCU6 on Aetrix. Our sales agent will provide a competitive quotation and guide you through the order confirmation once you accept the terms.
2.Are the price and stock information for STM32L452CCU6 reliable?
The price and inventory of STM32L452CCU6 are updated periodically and may fluctuate due to market conditions. Stock and pricing data are typically refreshed every 24 hours. Quotation validity for STM32L452CCU6 is usually 5 days.
3.What payment methods are accepted for STM32L452CCU6?
We accept Wire Transfer, PayPal, Credit Card, Western Union, MoneyGram, and Escrow for STM32L452CCU6 transactions.
Note: Certain payment methods may incur a processing fee.
4.How is shipping managed for STM32L452CCU6?
STM32L452CCU6 orders can be shipped via leading logistics carriers, including DHL, UPS, FedEx, TNT, or Registered Mail.
Once your STM32L452CCU6 order is processed, you will receive an email with the shipment details and tracking number.
Note: Tracking information may take up to 24 hours to appear. Express delivery typically takes 3–5 business days.
5.How can I obtain technical support or documentation for STM32L452CCU6?
For technical support, including STM32L452CCU6 datasheets, pinout diagrams, or application guidance, please contact our engineering support team. They can provide detailed documentation and assistance for your STM32L452CCU6 requirements.
6.How does Aetrix verify that STM32L452CCU6 is sourced from the original manufacturer or authorized distributors?
All STM32L452CCU6 products on Aetrix are procured from qualified distributors and authorized channels. Our dedicated quality assurance team conducts strict verification, including traceability checks and, if necessary, third-party testing. This ensures that STM32L452CCU6 meets industry standards.
7.What is the process for return or replacement of STM32L452CCU6?
All STM32L452CCU6 units undergo pre-shipment inspection (PSI). If there is an issue with STM32L452CCU6, returns or replacements are accepted under the following conditions:
1.Quantity discrepancies, incorrect items, or visible external defects (such as breakage or corrosion), acknowledged by Aetrix.
2.The issue is reported within 90 days of delivery.
3.The STM32L452CCU6 part is unused and in its original packaging.
Return procedure for STM32L452CCU6:
1.Submit a request within 90 days.
2.Obtain a Return Material Authorization (RMA) from Aetrix.
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