STMicroelectronics STM32L452REI6

Overview

STM32L452REI6 from STMicroelectronics is an ultra-low-power Arm® Cortex®-M4 32-bit MCU with FPU, operating up to 80 MHz (100 DMIPS), featuring 512 KB Flash, 160 KB SRAM, and integrated analog peripherals including 12-bit ADC (5 Msps), dual 12-bit DAC, op-amp with PGA, and ultra-low-power comparators. It supports external SMPS for 36 µA/MHz run-mode efficiency and targets battery-powered industrial sensors and portable medical devices requiring RTC, capacitive touch, and USB full-speed connectivity.

For engineers reviewing the STM32L452REI6 datasheet, STM32L452REI6 pinout, STM32L452REI6 application, or STM32L452REI6 equivalent, key selection criteria include verified ultra-low-power modes (22 nA Shutdown, 375 nA Standby + RTC), LQFP64 package compatibility, CAN 2.0B interface support, SAI audio interface, and hardware parity-protected SRAM for functional safety-critical firmware.

Technical Context

The STM32L452REI6 implements an Adaptive Real-time Accelerator (ART Accelerator™) enabling zero-wait-state execution from Flash at 80 MHz, paired with a Memory Protection Unit (MPU) and interconnect matrix for deterministic peripheral arbitration. Its power architecture integrates dual voltage regulators (LDO and SMPS interface), brown-out reset (BOR), and five wakeup-capable pins across all low-power modes.

Clock system includes dual PLLs (system/audio/ADC), auto-trimmed multispeed oscillator (±0.25%), 4–48 MHz crystal support, and 32 kHz LSE for RTC calibration. Analog subsystem features independent supply domains, hardware oversampling (up to 16-bit), and buffered 2.048 V/2.5 V reference outputs with ±1.5% accuracy over temperature.

Key Specifications

Pinout & Package

LQFP64 (10 × 10 mm, 0.5 mm pitch) with exposed thermal pad; RoHS-compliant ECOPACK2® packaging. Pin count: 64 terminals, including 51 general-purpose I/Os (most 5 V-tolerant), dedicated debug (SWD/JTAG), USB D+/D−, CAN H/L, SAI, and analog input/output channels.

Key Features

Applications

Equivalent & Alternatives

The following parts are listed as comparable options for similar ultra-low-power Cortex-M4 MCU applications.

Compared with STM32L452REI6, STM32L476RG trades audio capability for networking features and larger memory, while STM32L552RE introduces mandatory security overhead (TrustZone, ECC) at the cost of 2.5× higher Stop-mode current and reduced analog peripheral count.

Availability

STM32L452REI6 is available at Aetrix Electronics and suitable for wireless sensor nodes, portable medical devices, industrial HMI panels, and smart energy meters requiring stable component supply across extended product lifecycles.

Supply support for STM32L452REI6 includes scheduled delivery planning, volume procurement assistance, BOM continuity management, traceable sourcing, and lifecycle availability coordination for OEM customers, industrial embedded developers, connected-device designers, and electronics production programs.

Manufacturer

STMicroelectronics is a global semiconductor leader headquartered in Geneva, designing and manufacturing microcontrollers, power ICs, sensors, and analog components for industrial, automotive, and consumer markets.

The STM32L4 series targets ultra-low-power embedded applications demanding high performance per µA, with the L452 variant optimized for mixed-signal edge devices combining precision analog, audio, and robust connectivity in compact LQFP64 packages.

FAQ

What is the maximum operating frequency and associated DMIPS rating?

The STM32L452REI6 operates at up to 80 MHz with an ARM Cortex-M4 core featuring FPU and ART Accelerator, delivering 100 DMIPS (1.25 DMIPS/MHz). This performance is sustained with zero-wait-state execution from Flash memory, confirmed by Drystone 2.1 benchmarking and validated across temperature ranges from –40 °C to +85 °C.

Does this MCU support crystal-less USB operation?

Yes, the STM32L452REI6 integrates a full-speed USB 2.0 interface with built-in crystal-less capability using its internal 48 MHz clock recovery system (CRS). It supports Link Power Management (LPM) and Battery Charging Detection (BCD), eliminating the need for an external USB crystal while maintaining ±0.25% timing accuracy per USB specification.

How many low-power modes are implemented, and what are their key current specs?

The device implements seven low-power modes: Shutdown (22 nA), Stop 2 (2.40 µA with RTC), Standby (106 nA), Standby + RTC (375 nA), and VBAT mode (145 nA). All values are measured at 3.3 V and 25 °C per DS11912 Rev 7, with five dedicated wakeup pins available in Shutdown, Stop 2, and Standby modes.

Is CAN 2.0B interface supported, and what physical layer requirements apply?

Yes, the STM32L452REI6 includes a Controller Area Network (CAN) 2.0B compliant peripheral with dedicated PD0 (CAN_RX) and PD1 (CAN_TX) pins. It requires an external CAN transceiver (e.g., TJA1042) for physical layer compliance; no internal transceiver is integrated, and bus termination must be implemented externally per ISO 11898-2.